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KMID : 0350519920450031045
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Journal of Catholic Medical College
1992 Volume.45 No. 3 p.1045 ~ p.1052
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Changes of Circulating Lymphocyte Subpopulation In the Acute Phase of Measles
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Abstract
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Measles virus infection is associated with a prolonged period of depressed cutaneous delayed type hypersensitivity responses and transient depression of cell mediated immune responses in vivo and in vitro. The depression of these responses
extends
for
several weeks beyond the clinical illness and its accompanying leukopenia.
Although a transient decrease in total lymphocyte is uniformly found early in measles virus infections, it has not been clear whether this reflects a decrease in all cells or in a particular subpopulation of cells, especially natural killer cell
and
interleukin-2 receptor positive cell.
This study was performed to investigate the changes of lymphocyte subpopulation in the acute phase of measles.
The patients were divided into three group: early acute phase, late acute phase and control. The early acute phase group consist of ten patients on the one day before and two days after the onset of the rash. And the late acute phase group
consist
of
twelve patients on the five to eight days after the onset of the rash.
We analyzed the circulating lymphocyte subpopulation using flow cytometer after immunocytochemical staining for cell surface antigens indication the types of cells(CD3, CD4, CD8, CD16, CD19 and CD25) with the peripheral blood in the early and
late
acute
phase of measles patients and control.
@ES The results were as follow:
@EN 1. The total blood cell counts in the early acute phase group were significantly decreased and returned to the control level in the late acute phase of measles. But the total neutrophile counts were not changed significantly during acute
phase
of
measles.
2. The total lymphocyte counts in the early acute phase group were slightly decreased and returned to the control level in the late acute phase of measles.
3. The T-cell counts in the early acute phase group were significantly decreased and returned to the control level in the late acute phase of measles.
4. The total B-cell counts were not changed significantly during acute phase of measles.
5. The ratio of helper T cell to suppressor T cell was not changed significantly during acute phase of measles.
6. The natural killer cell counts in the early acute phase group were significantly decreased and returned to the control level in the late acute phase of measles.
7. The percentages of interleukin-2 receptor positive cells in the early and late acute phase group were significantly decreased when compared with control patients.
In conclusions, our data suggested the decrease of peripheral lymphocyte subpopulation counts, especially T cell, natural killer cell, were presented in the early acute and these findings were returned to normal in the late acute phase of measles
virus
infection.
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KEYWORD
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